Genetics and Methylation
Methylation and MTHFR
Methylation is the passing of a chemical called a methyl group (a carbon atom linked to three hydrogen atoms) from one molecule to another. The easiest way to understand methylation is to think of it as a domino effect in your body.
The Methylation cycle is responsible for the function of:
The MTHFR gene provides instruction for making an enzyme called "methylenetetrahydrofolate reductase." This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also known as folic acid or vitamin B9). Specifically, this enzyme converts 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.
A single-nucleotide polymorphism (SNP, pronounced snip; plural snips) is a DNA sequence variation occurring when a single nucleotide- A, T, C or G- in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes in a human.
Functions of Methylation
- Epigenetics (turns genes on/off)
- Protects and Stabilizes DNA
- Activates and/or Deactivates Stress Hormones
- Activates Serotonin, Melatonin and Dopamine
- Energy (ATP) Production
- Growth and Healing
- Autonomic Nervous System (ANS)
- Immune System
Methylation Signs and Symptoms
- Chronic Fatigue
- Sleep Disorders
- Inability to Adapt to Stress
- Toxic Encephalitis
- Genetic Disorders
- Hormone Dysregulation
What Causes Your Methylation to Fail?
There are many variables involved in a faulty Methlyation cycle, such as:
- Over consumption of sugar
- Deficiency of B12 or Folate
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